# Structure of huge protein complex in methane-producing microbes revealed

Researchers determined the architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly, a key enzyme complex in class I methanogens. This structural insight advances understanding of how these archaea produce methane, a potent greenhouse gas, and could inform efforts to harness or mitigate microbial methane generation.

**Importance:** 3/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10744-9) — 2026-07-08