# Mitochondrial metabolism and epigenetic interaction drive SASP

Researchers discovered that mitochondrial metabolism and epigenetic changes work together to control the senescence-associated secretory phenotype (SASP), a key driver of aging and inflammation. This crosstalk reveals a new mechanism that could lead to therapies for age-related diseases.

**Importance:** 3/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10791-2) — 2026-07-29