# New 3D Patient-Derived Models Map Cancer Dependencies

Researchers have published a compendium of next-generation patient-derived 3D cancer models spanning diverse tumor types, paired with a detailed dependency map. These models allow systematic identification of genetic vulnerabilities in cancers that are difficult to study in standard 2D cultures. The resource is expected to accelerate precision oncology by revealing new therapeutic targets and improving drug testing.

**Importance:** 3/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10843-7) — 2026-08-05
- [Nature](https://www.nature.com/articles/s41586-026-10806-y) — 2026-08-05