# New phosphine method couples azine C-H bonds with water and ammonia

Researchers report a phosphine-mediated approach to directly couple carbon-hydrogen bonds in azines with water or ammonia, enabling efficient functionalization of these heterocycles. The method bypasses pre-functionalized starting materials, offering a simpler route to valuable nitrogen-containing compounds used in pharmaceuticals and agrochemicals. Published in Nature, the advance could streamline synthesis of complex molecules.

**Importance:** 3/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10991-w) — 2026-08-11