# Pyridoxal photoenzymes enable asymmetric radical cross-couplings

Researchers have engineered pyridoxal-based photoenzymes to catalyze asymmetric radical–radical cross-coupling reactions, a challenging transformation in synthetic chemistry. This method allows precise control over stereochemistry, offering a new tool for constructing chiral molecules important in pharmaceuticals and materials. The work expands the scope of biocatalysis in creating complex molecular architectures under mild conditions.

**Importance:** 4/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10930-9) — 2026-07-27