# Modular antibody-ADC click method reverses drug resistance in tumors

Researchers have developed a modular in vivo click chemistry approach that uses antibodies and antibody-drug conjugates (ADCs) to reverse drug resistance in tumors. The technique enables targeted delivery and activation of therapeutics directly within the tumor microenvironment. This breakthrough could lead to new strategies for overcoming a major obstacle in cancer treatment.

**Importance:** 4/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-10789-w) — 2026-07-15