Two boys with severe epilepsy received custom gene therapies that dramatically reduced their seizures. The treatments targeted the specific genetic mutations causing their conditions. This breakthrough suggests that personalized gene therapy could become a viable approach for treating certain forms of epilepsy.

Scientists from New Scientist report that the upcoming El Niño is predicted to be the hottest on record by a significant margin. This could intensify extreme weather events globally, including heatwaves, floods, and droughts. The unprecedented warming highlights the accelerating climate crisis.

A mathematician has been awarded the prestigious Fields Medal for groundbreaking work that bridges fundamental physics and mathematics, aiming to unify the laws of nature. The prize, often seen as the Nobel of mathematics, highlights how deep theoretical insights can reshape our understanding of the universe. This recognition signals a major step toward a unified theory, influencing both mathematics and physics.

A new scientific paper challenges the standard cosmological model by claiming that dark energy is not real. The authors propose an alternative explanation for the universe's accelerating expansion. If accepted, this could fundamentally alter our understanding of the cosmos and drive new research in physics.

A study reveals that previous treatments determine the genetic mutations found in childhood cancers when they return. This finding helps explain drug resistance and could inform more effective therapies for relapsed cases.

New research indicates that geomagnetic storms caused by solar wind could be more intense than previously modeled. This finding is important for improving space weather forecasts and protecting satellites, power grids, and astronauts from severe solar activity.

Artificial intelligence has identified key molecular interactions within CRISPR complexes that influence editing accuracy. By understanding these interactions, researchers can improve the specificity of DNA editing, reducing off-target effects. This breakthrough published in Nature paves the way for safer and more reliable genome editing in medical and agricultural applications.

Researchers have developed a new method for precise DNA knock-in that avoids double-strand breaks, a major source of unwanted mutations in gene editing. The technique uses a programmable approach to insert genes efficiently and accurately. This advance could significantly improve the safety and efficacy of gene therapies for genetic disorders.

Researchers have used artificial intelligence to redesign both the starting sequences and the target outcomes in protein directed evolution, significantly enhancing the efficiency of the process. This approach could accelerate the development of novel proteins for medical therapies, industrial enzymes, and other applications by reducing the number of experimental iterations needed.