New phosphine method couples azine C-H bonds with water and ammonia

Researchers report a phosphine-mediated approach to directly couple carbon-hydrogen bonds in azines with water or ammonia, enabling efficient functionalization of these heterocycles. The method bypasses pre-functionalized starting materials, offering a simpler route to valuable nitrogen-containing compounds used in pharmaceuticals and agrochemicals. Published in Nature, the advance could streamline synthesis of complex molecules.

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