Pyridoxal photoenzymes enable asymmetric radical cross-couplings

Researchers have engineered pyridoxal-based photoenzymes to catalyze asymmetric radical–radical cross-coupling reactions, a challenging transformation in synthetic chemistry. This method allows precise control over stereochemistry, offering a new tool for constructing chiral molecules important in pharmaceuticals and materials. The work expands the scope of biocatalysis in creating complex molecular architectures under mild conditions.

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